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Protective Effect of Crocin on Immune Checkpoint Inhibitors-Related Myocarditis Through Inhibiting NLRP3 Mediated Pyroptosis in Cardiomyocytes via NF-κB Pathway

PURPOSE: Immune checkpoint inhibitors (ICIs)-related myocarditis is now one of the most critical immune-related adverse effects (irAEs) in tumor immunotherapy, which has raised great concern in cardio-oncology. The pathogenesis involved in cardiac injury remains elusive. Crocin, the main component o...

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Detalles Bibliográficos
Autores principales:	Zhang, Hui, Lin, Jinyi, Shen, Yihui, Pan, Jianan, Wang, Chunhui, Cheng, Leilei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906878/ https://www.ncbi.nlm.nih.gov/pubmed/35282269 http://dx.doi.org/10.2147/JIR.S348464

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