Structural basis for mismatch surveillance by CRISPR–Cas9

CRISPR–Cas9 as a programmable genome editing tool is hindered by off-target DNA cleavage(1–4), and the underlying mechanisms by which Cas9 recognizes mismatches are poorly understood(5–7). Although Cas9 variants with greater discrimination against mismatches have been designed(8–10), these suffer fr...

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Detalles Bibliográficos
Autores principales: Bravo, Jack P. K., Liu, Mu-Sen, Hibshman, Grace N., Dangerfield, Tyler L., Jung, Kyungseok, McCool, Ryan S., Johnson, Kenneth A., Taylor, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907077/
https://www.ncbi.nlm.nih.gov/pubmed/35236982
http://dx.doi.org/10.1038/s41586-022-04470-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907077/
https://www.ncbi.nlm.nih.gov/pubmed/35236982
http://dx.doi.org/10.1038/s41586-022-04470-1

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