Inhibition of the hexamerization of SARS-CoV-2 endoribonuclease and modeling of RNA structures bound to the hexamer

Non-structural protein 15 (Nsp15) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) forms a homo hexamer and functions as an endoribonuclease. Here, we propose that Nsp15 activity may be inhibited by preventing its hexamerization through drug binding. We first explored the stable confo...

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Detalles Bibliográficos
Autores principales: Tran, Duy Phuoc, Taira, Yuta, Ogawa, Takumi, Misu, Ryoga, Miyazawa, Yoshiki, Kitao, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907205/
https://www.ncbi.nlm.nih.gov/pubmed/35264667
http://dx.doi.org/10.1038/s41598-022-07792-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907205/
https://www.ncbi.nlm.nih.gov/pubmed/35264667
http://dx.doi.org/10.1038/s41598-022-07792-2

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