secDrug: a pipeline to discover novel drug combinations to kill drug-resistant multiple myeloma cells using a greedy set cover algorithm and single-cell multi-omics

Multiple myeloma, the second-most common hematopoietic malignancy in the United States, still remains an incurable disease with dose-limiting toxicities and resistance to primary drugs like proteasome inhibitors (PIs) and Immunomodulatory drugs (IMiDs). We have created a computational pipeline that...

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Detalles Bibliográficos
Autores principales: Kumar, Harish, Mazumder, Suman, Chakravarti, Sayak, Sharma, Neeraj, Mukherjee, Ujjal Kumar, Kumar, Shaji, Baughn, Linda B, Van Ness, Brian G, Mitra, Amit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907243/
https://www.ncbi.nlm.nih.gov/pubmed/35264575
http://dx.doi.org/10.1038/s41408-022-00636-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907243/
https://www.ncbi.nlm.nih.gov/pubmed/35264575
http://dx.doi.org/10.1038/s41408-022-00636-2

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