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Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). The molecular players that can enhance OPC differentiation or rejuvenate OPCs are unclear. Here we show...

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Detalles Bibliográficos
Autores principales: Ma, Xiao-Ru, Zhu, Xudong, Xiao, Yujie, Gu, Hui-Min, Zheng, Shuang-Shuang, Li, Liang, Wang, Fan, Dong, Zhao-Jun, Wang, Di-Xian, Wu, Yang, Yang, Chenyu, Jiang, Wenhong, Yao, Ke, Yin, Yue, Zhang, Yang, Peng, Chao, Gao, Lixia, Meng, Zhuoxian, Hu, Zeping, Liu, Chong, Li, Li, Chen, Hou-Zao, Shu, Yousheng, Ju, Zhenyu, Zhao, Jing-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907257/
https://www.ncbi.nlm.nih.gov/pubmed/35264567
http://dx.doi.org/10.1038/s41467-022-28844-1