PET in vivo generators (134)Ce and (140)Nd on an internalizing monoclonal antibody probe

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The in vivo-generator radionuclides (140)Nd (t(1/2) = 3.4 d) and (134)Ce (t(1/2) = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair...

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Detalles Bibliográficos
Autores principales: Severin, G. W., Fonslet, J., Kristensen, L. K., Nielsen, C. H., Jensen, A. I., Kjær, A., Mazar, A. P., Johnston, K., Köster, U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907281/
https://www.ncbi.nlm.nih.gov/pubmed/35264588
http://dx.doi.org/10.1038/s41598-022-07147-x
Descripción
Sumario:The in vivo-generator radionuclides (140)Nd (t(1/2) = 3.4 d) and (134)Ce (t(1/2) = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides (134)La and (140)Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides (134)Ce and (140)Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like (177)Lu, (161)Tb and (225)Ac when internalizing bioconjugates are employed.

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