An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression

Most cancer causal variants are found in gene regulatory elements, e.g., enhancers. However, enhancer variants predisposing to hepatocellular carcinoma (HCC) remain unreported. Here we conduct a genome-wide survey of HCC-susceptible enhancer variants through a three-stage association study in 11,958...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Ting, Ni, Ting, Chen, Jiaxuan, Chen, Haitao, Ma, Xiaopin, Cao, Guangwen, Wu, Tianzhi, Xie, Haisheng, Zhou, Bin, Wei, Gang, Saiyin, Hexige, Shen, Suqin, Yu, Peng, Xiao, Qianyi, Liu, Hui, Gao, Yuzheng, Long, Xidai, Yin, Jianhua, Guo, Yanfang, Wu, Jiaxue, Wei, Gong-Hong, Hou, Jinlin, Jiang, De-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907293/
https://www.ncbi.nlm.nih.gov/pubmed/35264579
http://dx.doi.org/10.1038/s41467-022-28861-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907293/
https://www.ncbi.nlm.nih.gov/pubmed/35264579
http://dx.doi.org/10.1038/s41467-022-28861-0

Ejemplares similares