Normalization of clonal diversity in gene therapy studies using shape constrained splines

Viral vectors are used to insert genetic material into semirandom genomic positions of hematopoietic stem cells which, after reinfusion into patients, regenerate the entire hematopoietic system. Hematopoietic cells originating from genetically modified stem cells will harbor insertions in specific g...

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Detalles Bibliográficos
Autores principales: Del Core, L., Cesana, D., Gallina, P., Secanechia, Y. N. Serina, Rudilosso, L., Montini, E., Wit, E. C., Calabria, A., Grzegorczyk, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907296/
https://www.ncbi.nlm.nih.gov/pubmed/35264585
http://dx.doi.org/10.1038/s41598-022-05837-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907296/
https://www.ncbi.nlm.nih.gov/pubmed/35264585
http://dx.doi.org/10.1038/s41598-022-05837-0

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