MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization

Glioblastoma (GBM) is a lethal brain cancer known for its potent immunosuppressive effects. Loss of Methylthioadenosine Phosphorylase (MTAP) expression, via gene deletion or epigenetic silencing, is one of the most common alterations in GBM. Here we show that MTAP loss in GBM cells is correlated wit...

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Detalles Bibliográficos
Autores principales: Hansen, Landon J., Yang, Rui, Roso, Kristen, Wang, Wenzhe, Chen, Lee, Yang, Qing, Pirozzi, Christopher J., He, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907307/
https://www.ncbi.nlm.nih.gov/pubmed/35264604
http://dx.doi.org/10.1038/s41598-022-07697-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907307/
https://www.ncbi.nlm.nih.gov/pubmed/35264604
http://dx.doi.org/10.1038/s41598-022-07697-0

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