Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43

Trans-activation response DNA-binding protein of 43  kDa (TDP-43) regulates RNA processing and forms neuropathological aggregates in patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Investigating TDP-43 post-translational modifications, we discovered that K84 acetyl...

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Detalles Bibliográficos
Autores principales: Garcia Morato, Jorge, Hans, Friederike, von Zweydorf, Felix, Feederle, Regina, Elsässer, Simon J., Skodras, Angelos A., Gloeckner, Christian Johannes, Buratti, Emanuele, Neumann, Manuela, Kahle, Philipp J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907366/
https://www.ncbi.nlm.nih.gov/pubmed/35264561
http://dx.doi.org/10.1038/s41467-022-28822-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907366/
https://www.ncbi.nlm.nih.gov/pubmed/35264561
http://dx.doi.org/10.1038/s41467-022-28822-7

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