Mesenchymal Stem Cells Exposed to Persistently High Glucocorticoid Levels Develop Insulin-Resistance and Altered Lipolysis: A Promising In Vitro Model to Study Cushing’s Syndrome

BACKGROUND: In Cushing’s syndrome (CS), chronic glucocorticoid excess (GC) and disrupted circadian rhythm lead to insulin resistance (IR), diabetes mellitus, dyslipidaemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells (MSCs) ma...

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Detalles Bibliográficos
Autores principales: Di Vincenzo, Mariangela, Martino, Marianna, Lariccia, Vincenzo, Giancola, Giulia, Licini, Caterina, Di Benedetto, Giovanni, Arnaldi, Giorgio, Orciani, Monia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907420/
https://www.ncbi.nlm.nih.gov/pubmed/35282448
http://dx.doi.org/10.3389/fendo.2022.816229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907420/
https://www.ncbi.nlm.nih.gov/pubmed/35282448
http://dx.doi.org/10.3389/fendo.2022.816229

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