Cargando…

Gasdermin-B Pro-Tumor Function in Novel Knock-in Mouse Models Depends on the in vivo Biological Context

Gasdermins (GSDM) genes play complex roles in inflammatory diseases and cancer. Gasdermin-B (GSDMB) is frequently upregulated in human cancers, especially in HER2-amplified breast carcinomas, and can promote diverse pro-tumor functions (invasion, metastasis, therapy-resistance). In particular, the G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarrio, David, Rojo-Sebastián, Alejandro, Teijo, Ana, Pérez-López, María, Díaz-Martín, Eva, Martínez, Lidia, Morales, Saleta, García-Sanz, Pablo, Palacios, José, Moreno-Bueno, Gema
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907722/ https://www.ncbi.nlm.nih.gov/pubmed/35281099 http://dx.doi.org/10.3389/fcell.2022.813929

Ejemplares similares

Gasdermin-B Promotes Invasion and Metastasis in Breast Cancer Cells
por: Hergueta-Redondo, Marta, et al.
Publicado: (2014)

Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer
por: Hergueta-Redondo, Marta, et al.
Publicado: (2016)

Biological Functions of Gasdermins in Cancer: From Molecular Mechanisms to Therapeutic Potential
por: Wang, Man, et al.
Publicado: (2021)

New insights into the evolutionary dynamic and lineage divergence of gasdermin E in metazoa
por: Yuan, Zihao, et al.
Publicado: (2022)

Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation
por: Gámez-Chiachio, Manuel, et al.
Publicado: (2022)

Pyroptosis and gasdermins—Emerging insights and therapeutic opportunities in metabolic dysfunction-associated steatohepatitis
por: Stoess, Christian, et al.
Publicado: (2023)

Gasdermin D Mediates Inflammation-Induced Defects in Reverse Cholesterol Transport and Promotes Atherosclerosis
por: Opoku, Emmanuel, et al.
Publicado: (2021)

Treatment of Severe Acute Pancreatitis and Related Lung Injury by Targeting Gasdermin D-Mediated Pyroptosis
por: Wu, Jinxiang, et al.
Publicado: (2021)

Not sorcery after all: Roles of multiple charged residues in membrane insertion of gasdermin-A3
por: Korn, Viktoria, et al.
Publicado: (2022)

Sevoflurane Aggravates the Progress of Alzheimer’s Disease Through NLRP3/Caspase-1/Gasdermin D Pathway
por: Tian, Di, et al.
Publicado: (2022)

Gasdermin E Deletion Attenuates Ureteral Obstruction- and 5/6 Nephrectomy-Induced Renal Fibrosis and Kidney Dysfunction
por: Wu, Mengying, et al.
Publicado: (2021)

Gasdermin-E Mediated Pyroptosis—A Novel Mechanism Regulating Migration, Invasion and Release of Inflammatory Cytokines in Rheumatoid Arthritis Fibroblast-like Synoviocytes
por: Wu, Tao, et al.
Publicado: (2022)

Novel regulation on the mitotic checkpoint revealed by knocking out CDC20
por: Wang, Ying, et al.
Publicado: (2023)

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification
por: Zhang, Lichen, et al.
Publicado: (2022)

The gasdermin-D pore: Executor of pyroptotic cell death
por: Rühl, Sebastian, et al.
Publicado: (2016)

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice
por: Zaytseva, Olga O., et al.
Publicado: (2020)

Knock-down of YME1L1 induces mitochondrial dysfunction during early porcine embryonic development
por: Zhou, Dongjie, et al.
Publicado: (2023)

Knock-Down of Histidyl-tRNA Synthetase Causes Cell Cycle Arrest and Apoptosis of Neuronal Progenitor Cells in vivo
por: Waldron, Ashley, et al.
Publicado: (2019)

Efficient CRISPR-Cas9-Mediated Knock-In of Composite Tags in Zebrafish Using Long ssDNA as a Donor
por: Ranawakage, Deshani C., et al.
Publicado: (2021)

TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
por: Lavanderos, Boris, et al.
Publicado: (2020)

Transcriptome Analysis of Dnmt3l Knock-Out Mice Derived Multipotent Mesenchymal Stem/Stromal Cells During Osteogenic Differentiation
por: Yang, Chih-Yi, et al.
Publicado: (2021)

Validation of a Novel Fgf10(Cre–ERT2) Knock-in Mouse Line Targeting FGF10(Pos) Cells Postnatally
por: Chu, Xuran, et al.
Publicado: (2021)

Editorial: Generation of Neurons and Their Integration in Pre-existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts
por: Mira, Helena, et al.
Publicado: (2020)

Putting Cells into Context
por: Stricker, Sigmar, et al.
Publicado: (2017)

Rapamycin and Resveratrol Modulate the Gliotic and Pro-Angiogenic Response in Müller Glial Cells Under Hypoxia
por: Subirada, Paula V., et al.
Publicado: (2022)

Novel Therapies and Strategies to Overcome Resistance to Anti-HER2-Targeted Drugs
por: Gámez-Chiachio, Manuel, et al.
Publicado: (2022)

The Social Component of Environmental Enrichment Is a Pro-neurogenic Stimulus in Adult c57BL6 Female Mice
por: Moreno-Jiménez, Elena P., et al.
Publicado: (2019)

b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region
por: Delbaere, Sarah, et al.
Publicado: (2020)

Functional characterization of E- and P-cadherin in invasive breast cancer cells
por: Sarrió, David, et al.
Publicado: (2009)

Editorial: DNA damage response in the context of chromatin
por: Zong, Dali, et al.
Publicado: (2023)

Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in ApoE Knock-Out Mice
por: Puylaert, Pauline, et al.
Publicado: (2022)

Microenvironment-Cell Nucleus Relationship in the Context of Oxidative Stress
por: Chittiboyina, Shirisha, et al.
Publicado: (2018)

The salamander blastema within the broader context of metazoan regeneration
por: Tajer, Benjamin, et al.
Publicado: (2023)

Effects of the SUMO Ligase BCA2 on Metabolic Activity, Cell Proliferation, Cell Migration, Cell Cycle, and the Regulation of NF-κB and IRF1 in Different Breast Epithelial Cellular Contexts
por: Shi, Yuhang, et al.
Publicado: (2021)

Developing a functional urinary bladder: a neuronal context
por: Keast, Janet R., et al.
Publicado: (2015)

Genome Editing Fidelity in the Context of DNA Sequence and Chromatin Structure
por: Chechik, Lyuba, et al.
Publicado: (2020)

Molecular Tuning of Filamin A Activities in the Context of Adhesion and Migration
por: Lamsoul, Isabelle, et al.
Publicado: (2020)

Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis
por: Bohaud, Candice, et al.
Publicado: (2021)

Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function
por: Sun, Wei, et al.
Publicado: (2021)

Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice
por: Huang, Shan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tfs99deq6u6bgi5mmhpndedfql