Chinese herbal component, Praeruptorin E, enhances anti-asthma efficacy and prevents toxicity of aminophylline by targeting the NF-κB/PXR/CYP3A4 pathway

BACKGROUND: Aminophylline is widely used for the treatment of asthma, but the therapeutic dose is very close to the toxic dose, which makes this drug prone to accumulation poisoning. In the present study, we explored whether the Chinese herbal component, Praeruptorin E (PE), enhances anti-asthma eff...

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Detalles Bibliográficos
Autores principales: Xu, Ronghua, Deng, Huiming, Gan, Lianfang, Zhong, Lifan, Deng, Yanxi, Wang, Qianru, Lv, Chuanzhu, Huang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908188/
https://www.ncbi.nlm.nih.gov/pubmed/35280431
http://dx.doi.org/10.21037/atm-22-386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908188/
https://www.ncbi.nlm.nih.gov/pubmed/35280431
http://dx.doi.org/10.21037/atm-22-386

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