Clinical Potential of Hypoxia Inducible Factors Prolyl Hydroxylase Inhibitors in Treating Nonanemic Diseases

Hypoxia inducible factors (HIFs) and their regulatory hydroxylases the prolyl hydroxylase domain enzymes (PHDs) are the key mediators of the cellular response to hypoxia. HIFs are normally hydroxylated by PHDs and degraded, while under hypoxia, PHDs are suppressed, allowing HIF-α to accumulate and t...

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Detalles Bibliográficos
Autores principales: Miao, Mengqiu, Wu, Mengqiu, Li, Yuting, Zhang, Lingge, Jin, Qianqian, Fan, Jiaojiao, Xu, Xinyue, Gu, Ran, Hao, Haiping, Zhang, Aihua, Jia, Zhanjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908211/
https://www.ncbi.nlm.nih.gov/pubmed/35281917
http://dx.doi.org/10.3389/fphar.2022.837249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908211/
https://www.ncbi.nlm.nih.gov/pubmed/35281917
http://dx.doi.org/10.3389/fphar.2022.837249

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