Oxidation of specific tryptophan residues inhibits high-affinity binding of cocaine and its metabolites to a humanized anticocaine mAb

Cocaine addiction remains a serious problem lacking an effective pharmacological treatment. Thus, we have developed a high-affinity anti-cocaine monoclonal antibody (mAb), h2E2, for the treatment of cocaine use disorders. We show that selective tryptophan (Trp) oxidation by 2,2′-azobis(2-amidinoprop...

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Detalles Bibliográficos
Autores principales: Kirley, Terence L., Norman, Andrew B., Greis, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908252/
https://www.ncbi.nlm.nih.gov/pubmed/35143837
http://dx.doi.org/10.1016/j.jbc.2022.101689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908252/
https://www.ncbi.nlm.nih.gov/pubmed/35143837
http://dx.doi.org/10.1016/j.jbc.2022.101689

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