In vitro reconstitution reveals cooperative mechanisms of adapter protein-mediated activation of phospholipase C-γ1 in T cells

Activation of T cells upon engagement of the T cell antigen receptor rapidly leads to a number of phosphorylation and plasma membrane recruitment events. For example, translocation of phospholipase-Cγ1 (PLC−γ1) to the plasma membrane and its association with the transmembrane adapter protein LAT and...

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Detalles Bibliográficos
Autores principales: Wada, Junya, Rathnayake, Udumbara, Jenkins, Lisa M., Singh, Avinash, Mohammadi, Moosa, Appella, Ettore, Randazzo, Paul A., Samelson, Lawrence E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908268/
https://www.ncbi.nlm.nih.gov/pubmed/35124007
http://dx.doi.org/10.1016/j.jbc.2022.101680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908268/
https://www.ncbi.nlm.nih.gov/pubmed/35124007
http://dx.doi.org/10.1016/j.jbc.2022.101680

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