A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas

Topoisomerases, targets of inhibitors used in chemotherapy, induce DNA breaks accumulation leading to cancer cell death. A newly synthesized copper(II) indenoisoquinoline complex WN197 exhibits a cytotoxic effect below 0.5 µM, on MDA-MB-231, HeLa, and HT-29 cells. At low doses, WN197 inhibits topois...

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Detalles Bibliográficos
Autores principales: Molinaro, Caroline, Wambang, Nathalie, Bousquet, Till, Vercoutter-Edouart, Anne-Sophie, Pélinski, Lydie, Cailliau, Katia, Martoriati, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908320/
https://www.ncbi.nlm.nih.gov/pubmed/35280788
http://dx.doi.org/10.3389/fonc.2022.837373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908320/
https://www.ncbi.nlm.nih.gov/pubmed/35280788
http://dx.doi.org/10.3389/fonc.2022.837373

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