Antimalarial Activity of Highly Coordinative Fused Heterocycles Targeting β-Hematin Crystallization

[Image: see text] The β-hematin formation is a unique process adopted by Plasmodium sp. to detoxify free heme and represents a validated target to design new effective antimalarials. Most of the β-hematin inhibitors are mainly based on 4-aminoquinolines, but the parasite has developed diverse defens...

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Detalles Bibliográficos
Autores principales: Acosta, María E., Gotopo, Lourdes, Gamboa, Neira, Rodrigues, Juan R., Henriques, Genesis C., Cabrera, Gustavo, Romero, Angel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908514/
https://www.ncbi.nlm.nih.gov/pubmed/35284702
http://dx.doi.org/10.1021/acsomega.1c05393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908514/
https://www.ncbi.nlm.nih.gov/pubmed/35284702
http://dx.doi.org/10.1021/acsomega.1c05393

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