Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

BACKGROUND: Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been developed and shown anticancer efficacy in preclinical settings,...

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Detalles Bibliográficos
Autores principales: Qi, Simin, Guan, Xiaoqing, Zhang, Jia, Yu, Dehua, Yu, Xuefei, Li, Qinglin, Yin, Wenjuan, Cheng, Xiang-Dong, Zhang, Weidong, Qin, Jiang-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908661/
https://www.ncbi.nlm.nih.gov/pubmed/35272681
http://dx.doi.org/10.1186/s12943-022-01538-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908661/
https://www.ncbi.nlm.nih.gov/pubmed/35272681
http://dx.doi.org/10.1186/s12943-022-01538-4

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