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Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis

BACKGROUND: Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been developed and shown anticancer efficacy in preclinical settings,...

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Detalles Bibliográficos
Autores principales:	Qi, Simin, Guan, Xiaoqing, Zhang, Jia, Yu, Dehua, Yu, Xuefei, Li, Qinglin, Yin, Wenjuan, Cheng, Xiang-Dong, Zhang, Weidong, Qin, Jiang-Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908661/ https://www.ncbi.nlm.nih.gov/pubmed/35272681 http://dx.doi.org/10.1186/s12943-022-01538-4

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