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The telomere-mitochondrial axis of aging in newborns
Aging starts at the beginning of life as evidenced by high variability in telomere length (TL) and mitochondrial DNA content (mtDNAc) at birth. Whether p53 and PGC-1α are connected to these age-related markers in early life is unclear. In this study, we hypothesized that these hallmarks of aging are...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908926/ https://www.ncbi.nlm.nih.gov/pubmed/35169104 http://dx.doi.org/10.18632/aging.203897 |
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author | Van Der Stukken, Charlotte Nawrot, Tim S. Alfano, Rossella Wang, Congrong Langie, Sabine A.S. Plusquin, Michelle Janssen, Bram G. Martens, Dries S. |
author_facet | Van Der Stukken, Charlotte Nawrot, Tim S. Alfano, Rossella Wang, Congrong Langie, Sabine A.S. Plusquin, Michelle Janssen, Bram G. Martens, Dries S. |
author_sort | Van Der Stukken, Charlotte |
collection | PubMed |
description | Aging starts at the beginning of life as evidenced by high variability in telomere length (TL) and mitochondrial DNA content (mtDNAc) at birth. Whether p53 and PGC-1α are connected to these age-related markers in early life is unclear. In this study, we hypothesized that these hallmarks of aging are associated at birth. In 613 newborns from the ENVIRONAGE birth cohort, p53 and PGC-1α protein levels were measured in cord plasma, while TL and mtDNAc were measured in both cord blood and placental tissue. Cord blood methylation data of genes corresponding to the measured protein levels were available from the Human MethylationEPIC 850K BeadChip array. Pearson correlations and linear regression models were applied while accounting for selected covariates. In cord, a 10% increase in TL was associated with 5.22% (95% CI: 3.26 to 7.22; p < 0.0001) higher mtDNAc and −2.66% (95% CI: –5.04 to −0.23%; p = 0.032) lower p53 plasma level. In placenta, a 10% increase in TL was associated with 5.46% (95% CI: 3.82 to 7.13%; p < 0.0001) higher mtDNAc and −2.42% (95% CI: −4.29 to −0.52; p = 0.0098) lower p53 plasma level. Methylation level of TP53 was correlated with TL and mtDNAc in cord blood and with cord plasma p53 level. Our study suggests that p53 may be an important factor both at the protein and methylation level for the telomere-mitochondrial axis of aging at birth. |
format | Online Article Text |
id | pubmed-8908926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-89089262022-03-11 The telomere-mitochondrial axis of aging in newborns Van Der Stukken, Charlotte Nawrot, Tim S. Alfano, Rossella Wang, Congrong Langie, Sabine A.S. Plusquin, Michelle Janssen, Bram G. Martens, Dries S. Aging (Albany NY) Research Paper Aging starts at the beginning of life as evidenced by high variability in telomere length (TL) and mitochondrial DNA content (mtDNAc) at birth. Whether p53 and PGC-1α are connected to these age-related markers in early life is unclear. In this study, we hypothesized that these hallmarks of aging are associated at birth. In 613 newborns from the ENVIRONAGE birth cohort, p53 and PGC-1α protein levels were measured in cord plasma, while TL and mtDNAc were measured in both cord blood and placental tissue. Cord blood methylation data of genes corresponding to the measured protein levels were available from the Human MethylationEPIC 850K BeadChip array. Pearson correlations and linear regression models were applied while accounting for selected covariates. In cord, a 10% increase in TL was associated with 5.22% (95% CI: 3.26 to 7.22; p < 0.0001) higher mtDNAc and −2.66% (95% CI: –5.04 to −0.23%; p = 0.032) lower p53 plasma level. In placenta, a 10% increase in TL was associated with 5.46% (95% CI: 3.82 to 7.13%; p < 0.0001) higher mtDNAc and −2.42% (95% CI: −4.29 to −0.52; p = 0.0098) lower p53 plasma level. Methylation level of TP53 was correlated with TL and mtDNAc in cord blood and with cord plasma p53 level. Our study suggests that p53 may be an important factor both at the protein and methylation level for the telomere-mitochondrial axis of aging at birth. Impact Journals 2022-02-15 /pmc/articles/PMC8908926/ /pubmed/35169104 http://dx.doi.org/10.18632/aging.203897 Text en Copyright: © 2022 Van Der Stukken et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Van Der Stukken, Charlotte Nawrot, Tim S. Alfano, Rossella Wang, Congrong Langie, Sabine A.S. Plusquin, Michelle Janssen, Bram G. Martens, Dries S. The telomere-mitochondrial axis of aging in newborns |
title | The telomere-mitochondrial axis of aging in newborns |
title_full | The telomere-mitochondrial axis of aging in newborns |
title_fullStr | The telomere-mitochondrial axis of aging in newborns |
title_full_unstemmed | The telomere-mitochondrial axis of aging in newborns |
title_short | The telomere-mitochondrial axis of aging in newborns |
title_sort | telomere-mitochondrial axis of aging in newborns |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908926/ https://www.ncbi.nlm.nih.gov/pubmed/35169104 http://dx.doi.org/10.18632/aging.203897 |
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