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Targeting HIF-2α in the Tumor Microenvironment: Redefining the Role of HIF-2α for Solid Cancer Therapy
SIMPLE SUMMARY: Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a known driver of tumor progression and therapeutic resistance. As oxygen levels decrease, transcription factor HIF-1α and...
Autores principales: | Davis, Leah, Recktenwald, Matthias, Hutt, Evan, Fuller, Schuyler, Briggs, Madison, Goel, Arnav, Daringer, Nichole |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909461/ https://www.ncbi.nlm.nih.gov/pubmed/35267567 http://dx.doi.org/10.3390/cancers14051259 |
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