LRRK2 Inhibition Mitigates the Neuroinflammation Caused by TLR2-Specific α-Synuclein and Alleviates Neuroinflammation-Derived Dopaminergic Neuronal Loss

Evidence suggests that crosstalk occurs between microglial leucine-rich repeat kinase 2 (LRRK2)—a regulator of neuroinflammation—and neuron-released α-synuclein (αSyn)—a promoter of microglial activation and neuroinflammatory responses—in neuroinflammation-mediated Parkinson’s disease (PD) progressi...

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Detalles Bibliográficos
Autores principales: Ho, Dong-Hwan, Nam, Daleum, Seo, Mikyoung, Park, Sung-Woo, Seol, Wongi, Son, Ilhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909553/
https://www.ncbi.nlm.nih.gov/pubmed/35269482
http://dx.doi.org/10.3390/cells11050861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909553/
https://www.ncbi.nlm.nih.gov/pubmed/35269482
http://dx.doi.org/10.3390/cells11050861

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