In Silico Designed Gain-of-Function Variants of Complement C2 Support Cytocidal Activity of Anticancer Monoclonal Antibodies

SIMPLE SUMMARY: The complement system can be exploited by anticancer antibody-based therapeutics. Activation of the classical complement pathway by the heavy chain of antibodies eventually leads to the lysis of target cells. However, overexpression of complement inhibitors by tumor cells limits the...

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Detalles Bibliográficos
Autores principales: Urban, Aleksandra, Majeranowski, Alan, Stasiłojć, Grzegorz, Koszałka, Patrycja, Felberg, Anna, Taszner, Michał, Zaucha, Jan M., Okrój, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909654/
https://www.ncbi.nlm.nih.gov/pubmed/35267578
http://dx.doi.org/10.3390/cancers14051270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909654/
https://www.ncbi.nlm.nih.gov/pubmed/35267578
http://dx.doi.org/10.3390/cancers14051270

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