Pseudotime Analysis Reveals Exponential Trends in DNA Methylation Aging with Mortality Associated Timescales

The epigenetic trajectory of DNA methylation profiles has a nonlinear relationship with time, reflecting rapid changes in DNA methylation early in life that progressively slow with age. In this study, we use pseudotime analysis to determine the functional form of these trajectories. Unlike epigeneti...

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Detalles Bibliográficos
Autores principales: Lapborisuth, Kalsuda, Farrell, Colin, Pellegrini, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909670/
https://www.ncbi.nlm.nih.gov/pubmed/35269389
http://dx.doi.org/10.3390/cells11050767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909670/
https://www.ncbi.nlm.nih.gov/pubmed/35269389
http://dx.doi.org/10.3390/cells11050767

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