Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53

The TP53 tumor suppressor is mutated in ~75% of pancreatic cancers. The mutant TP53 protein in pancreatic ductal adenocarcinomas (PDAC) promotes tumor growth and metastasis. Attempts have been made to develop molecules that restore at least some of the properties of wild-type (WT) TP53. APR-246 is o...

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Detalles Bibliográficos
Autores principales: Abrams, Stephen L., Duda, Przemysław, Akula, Shaw M., Steelman, Linda S., Follo, Matilde L., Cocco, Lucio, Ratti, Stefano, Martelli, Alberto M., Montalto, Giuseppe, Emma, Maria Rita, Cervello, Melchiorre, Rakus, Dariusz, Gizak, Agnieszka, McCubrey, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909756/
https://www.ncbi.nlm.nih.gov/pubmed/35269416
http://dx.doi.org/10.3390/cells11050794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909756/
https://www.ncbi.nlm.nih.gov/pubmed/35269416
http://dx.doi.org/10.3390/cells11050794

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