Anticancer Activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a New Dishevelled 1 Inhibitor

SIMPLE SUMMARY: The WNT/β-catenin pathway regulates a huge number of cellular functions, and its dysregulation is correlated to the development of cancer. In this work, we focused on the interaction between Dishevelled 1 (DVL1) protein, an important player in this pathway, and its cognate receptor F...

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Detalles Bibliográficos
Autores principales: Coluccia, Antonio, Bufano, Marianna, La Regina, Giuseppe, Puxeddu, Michela, Toto, Angelo, Paone, Alessio, Bouzidi, Amani, Musto, Giorgia, Badolati, Nadia, Orlando, Viviana, Biagioni, Stefano, Masci, Domiziana, Cantatore, Chiara, Cirilli, Roberto, Cutruzzolà, Francesca, Gianni, Stefano, Stornaiuolo, Mariano, Silvestri, Romano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909805/
https://www.ncbi.nlm.nih.gov/pubmed/35267666
http://dx.doi.org/10.3390/cancers14051358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909805/
https://www.ncbi.nlm.nih.gov/pubmed/35267666
http://dx.doi.org/10.3390/cancers14051358

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