An Orally Bioavailable and Highly Efficacious Inhibitor of CDK9/FLT3 for the Treatment of Acute Myeloid Leukemia

SIMPLE SUMMARY: CDDD11-8 is an orally bioactive pharmacological inhibitor of CDK9. In AML cells, CDDD11-8 suppressed the proliferation and caused robust inhibition of tumor growth in vivo via synergistic inhibition of FLT3. The drug candidate has potential to overcome cancer cell resistance to FLT3...

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Detalles Bibliográficos
Autores principales: Anshabo, Abel Tesfaye, Bantie, Laychiluh, Diab, Sarah, Lenjisa, Jimma, Kebede, Alemwork, Long, Yi, Heinemann, Gary, Karanjia, Jasmine, Noll, Benjamin, Basnet, Sunita K. C., Li, Manjun, Milne, Robert, Albrecht, Hugo, Wang, Shudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909834/
https://www.ncbi.nlm.nih.gov/pubmed/35267421
http://dx.doi.org/10.3390/cancers14051113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909834/
https://www.ncbi.nlm.nih.gov/pubmed/35267421
http://dx.doi.org/10.3390/cancers14051113

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