Cargando…

Dual Effect of Combined Metformin and 2-Deoxy-D-Glucose Treatment on Mitochondrial Biogenesis and PD-L1 Expression in Triple-Negative Breast Cancer Cells

SIMPLE SUMMARY: Metformin and 2-deoxy-D-glucose are metabolic drugs with multiple and incompletely understood anti-cancer effects. Their combination can cause breast cancer cell detachment from the growth surface. Mitochondria are important for detached cell survival and metastasis, but how metformi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Repas, Jernej, Zupin, Mateja, Vodlan, Maja, Veranič, Peter, Gole, Boris, Potočnik, Uroš, Pavlin, Mojca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909901/ https://www.ncbi.nlm.nih.gov/pubmed/35267651 http://dx.doi.org/10.3390/cancers14051343

Ejemplares similares

Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells
por: Repas, Jernej, et al.
Publicado: (2021)

Pre-Treatment Biomarkers of Anti-Tumour Necrosis Factor Therapy Response in Crohn’s Disease—A Systematic Review and Gene Ontology Analysis
por: Gole, Boris, et al.
Publicado: (2019)

Omics data integration identifies ELOVL7 and MMD gene regions as novel loci for adalimumab response in patients with Crohn’s disease
por: Gorenjak, Mario, et al.
Publicado: (2021)

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening
por: Goričan, Larisa, et al.
Publicado: (2020)

Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro
por: Bizjak, Maruša, et al.
Publicado: (2017)

Adhesion and Stiffness of Detached Breast Cancer Cells In Vitro: Co-Treatment with Metformin and 2-Deoxy-d-glucose Induces Changes Related to Increased Metastatic Potential
por: Zemljič-Jokhadar, Špela, et al.
Publicado: (2021)

Macrophage polarization during Streptococcus agalactiae infection is isolate specific
por: Janžič, Larisa, et al.
Publicado: (2023)

Pre-treatment Risk Assessment of Women with Endometrial Cancer: Differences in Outcomes of Molecular and Clinical Classifications in The Slovenian Patient Cohort
por: Knez, Jure, et al.
Publicado: (2021)

Attachment of Cancer Urothelial Cells to the Bladder Epithelium Occurs on Uroplakin-Negative Cells and Is Mediated by Desmosomal and Not by Classical Cadherins
por: Jerman, Urška Dragin, et al.
Publicado: (2021)

Alterations in immunophenotype and metabolic profile of mononuclear cells during follow up in children with multisystem inflammatory syndrome (MIS-C)
por: Kopitar, Andreja Nataša, et al.
Publicado: (2023)

Cell type-specific response to high intracellular loading of polyacrylic acid-coated magnetic nanoparticles
por: Lojk, Jasna, et al.
Publicado: (2015)

How Cancer Cells Invade Bladder Epithelium and Form Tumors: The Mouse Bladder Tumor Model as a Model of Tumor Recurrence in Patients
por: Erman, Andreja, et al.
Publicado: (2021)

Cleavage-Mediated Regulation of Myd88 Signaling by Inflammasome-Activated Caspase-1
por: Avbelj, Monika, et al.
Publicado: (2022)

Visualization of internalization of functionalized cobalt ferrite nanoparticles and their intracellular fate
por: Bregar, Vladimir B, et al.
Publicado: (2013)

Peripheral Blood Transcriptome in Breast Cancer Patients as a Source of Less Invasive Immune Biomarkers for Personalized Medicine, and Implications for Triple Negative Breast Cancer
por: Čelešnik, Helena, et al.
Publicado: (2022)

Proposing Urothelial and Muscle In Vitro Cell Models as a Novel Approach for Assessment of Long-Term Toxicity of Nanoparticles
por: Skočaj, Matej, et al.
Publicado: (2020)

Medium Renewal Blocks Anti-Proliferative Effects of Metformin in Cultured MDA-MB-231 Breast Cancer Cells
por: Rajh, Maruša, et al.
Publicado: (2016)

Analysis of the Direct and Indirect Effects of Nanoparticle Exposure on Microglial and Neuronal Cells In Vitro
por: Lojk, Jasna, et al.
Publicado: (2020)

Dysregulation of Synaptic Signaling Genes Is Involved in Biology of Uterine Leiomyoma
por: Krsteski, Jovan, et al.
Publicado: (2021)

Safety and tolerability of dapagliflozin, saxagliptin and metformin in combination: Post‐hoc analysis of concomitant add‐on versus sequential add‐on to metformin and of triple versus dual therapy with metformin
por: Del Prato, Stefano, et al.
Publicado: (2018)

Highly Divergent Clostridium difficile Strains Isolated from the Environment
por: Janezic, Sandra, et al.
Publicado: (2016)

Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin
por: Chen, Shaomeng, et al.
Publicado: (2021)

Effect of metformin monotherapy and dual or triple concomitant therapy with metformin on glycemic control and lipid profile management of patients with type 2 diabetes mellitus
por: Lin, Yan-Yu, et al.
Publicado: (2022)

High-Resolution Melting Curve Analysis for High-Throughput Genotyping of NOD2/CARD15 Mutations and Distribution of These Mutations in Slovenian Inflammatory Bowel Diseases Patients
por: Mitrovič, Mitja, et al.
Publicado: (2011)

Blood-Based mRNA Tests as Emerging Diagnostic Tools for Personalised Medicine in Breast Cancer
por: Čelešnik, Helena, et al.
Publicado: (2023)

Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes
por: Jiang, Shaoning, et al.
Publicado: (2020)

The Phospholipase Activity of Ammodytoxin, a Prototype Snake Venom β-Neurotoxin, Is Not Obligatory for Cell Internalisation and Translocation to Mitochondria
por: Ivanušec, Adrijan, et al.
Publicado: (2022)

Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells
por: Resnik, Nataša, et al.
Publicado: (2015)

Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress
por: Kuret, Tadeja, et al.
Publicado: (2023)

The Relevance of Physico-Chemical Properties and Protein Corona for Evaluation of Nanoparticles Immunotoxicity—In Vitro Correlation Analysis on THP-1 Macrophages
por: Pavlin, Mojca, et al.
Publicado: (2022)

MFUM-BrTNBC-1, a Newly Established Patient-Derived Triple-Negative Breast Cancer Cell Line: Molecular Characterisation, Genetic Stability, and Comprehensive Comparison with Commercial Breast Cancer Cell Lines
por: Skok, Kristijan, et al.
Publicado: (2021)

Poly-L-lysine as an Effective and Safe Desquamation Inducer of Urinary Bladder Epithelium
por: Kerec Kos, Mojca, et al.
Publicado: (2019)

Molecular Dynamics Simulations Predict that rSNP Located in the HNF-1α Gene Promotor Region Linked with MODY3 and Hepatocellular Carcinoma Promotes Stronger Binding of the HNF-4α Transcription Factor
por: Španinger, Eva, et al.
Publicado: (2020)

Gene Ontology Analysis Highlights Biological Processes Influencing Non-Response to Anti-TNF Therapy in Rheumatoid Arthritis
por: Jezernik, Gregor, et al.
Publicado: (2022)

MIF Variant rs755622 Is Associated with Severe Crohn’s Disease and Better Response to Anti-TNF Adalimumab Therapy
por: Jezernik, Gregor, et al.
Publicado: (2023)

Gene Ontology Analysis Highlights Biological Processes Influencing Responsiveness to Biological Therapy in Psoriasis
por: Krušič, Martina, et al.
Publicado: (2023)

Human Amniotic Membrane Enriched with Urinary Bladder Fibroblasts Promote the Re-Epithelization of Urothelial Injury
por: Jerman, Urška Dragin, et al.
Publicado: (2020)

New Insights into the Mechanisms of Gene Electrotransfer – Experimental and Theoretical Analysis
por: Pavlin, Mojca, et al.
Publicado: (2015)

A Novel Strain of Porcine Adenovirus Detected in Urinary Bladder Urothelial Cell Culture
por: Jerman, Urška Dragin, et al.
Publicado: (2014)

1-Deoxy-l-mannitol (6-deoxy-l-mannitol or l-rhamnitol)
por: Jenkinson, Sarah F., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_ddrt897387osp40lap5bbh8jec