Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation

Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and can lead to severe dilated cardiomyopathy. We recently reported that pre-emptive depletion of PLN attenuated heart failure (HF) in several...

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Detalles Bibliográficos
Autores principales: Eijgenraam, Tim R., Stege, Nienke M., Oliveira Nunes Teixeira, Vivian, de Brouwer, Remco, Schouten, Elisabeth M., Grote Beverborg, Niels, Sun, Liu, Später, Daniela, Knöll, Ralph, Hansson, Kenny M., Amilon, Carl, Janzén, David, Yeh, Steve T., Mullick, Adam E., van der Meer, Peter, de Boer, Rudolf A., Silljé, Herman H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909937/
https://www.ncbi.nlm.nih.gov/pubmed/35269571
http://dx.doi.org/10.3390/ijms23052427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909937/
https://www.ncbi.nlm.nih.gov/pubmed/35269571
http://dx.doi.org/10.3390/ijms23052427

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