Bivalent EGFR-Targeting DARPin-MMAE Conjugates

Epidermal growth factor receptor (EGFR) is a validated tumor marker overexpressed in various cancers such as squamous cell carcinoma (SSC) of the head and neck and gliomas. We constructed protein-drug conjugates based on the anti-EGFR Designed Ankyrin Repeat Protein (DARPin) E01, and compared the bi...

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Detalles Bibliográficos
Autores principales: Karsten, Lennard, Janson, Nils, Le Joncour, Vadim, Alam, Sarfaraz, Müller, Benjamin, Tanjore Ramanathan, Jayendrakishore, Laakkonen, Pirjo, Sewald, Norbert, Müller, Kristian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909960/
https://www.ncbi.nlm.nih.gov/pubmed/35269611
http://dx.doi.org/10.3390/ijms23052468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909960/
https://www.ncbi.nlm.nih.gov/pubmed/35269611
http://dx.doi.org/10.3390/ijms23052468

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