Deciphering the Effect of Lysine Acetylation on the Misfolding and Aggregation of Human Tau Fragment (171)IPAKTPPAPK(180) Using Molecular Dynamic Simulation and the Markov State Model

The formation of neurofibrillary tangles (NFT) with β-sheet-rich structure caused by abnormal aggregation of misfolded microtubule-associated protein Tau is a hallmark of tauopathies, including Alzheimer’s Disease. It has been reported that acetylation, especially K174 located in the proline-rich re...

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Detalles Bibliográficos
Autores principales: Shah, Syed Jawad Ali, Zhong, Haiyang, Zhang, Qianqian, Liu, Huanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910285/
https://www.ncbi.nlm.nih.gov/pubmed/35269542
http://dx.doi.org/10.3390/ijms23052399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910285/
https://www.ncbi.nlm.nih.gov/pubmed/35269542
http://dx.doi.org/10.3390/ijms23052399

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