New Insights into the Interaction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition

The fourth enzymatic reaction in the de novo pyrimidine biosynthesis, the oxidation of dihydroorotate to orotate, is catalyzed by dihydroorotate dehydrogenase (DHODH). Enzymes belonging to the DHODH Class II are membrane-bound proteins that use ubiquinones as their electron acceptors. We have design...

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Detalles Bibliográficos
Autores principales: Orozco Rodriguez, Juan Manuel, Wacklin-Knecht, Hanna P., Clifton, Luke A., Bogojevic, Oliver, Leung, Anna, Fragneto, Giovanna, Knecht, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910288/
https://www.ncbi.nlm.nih.gov/pubmed/35269583
http://dx.doi.org/10.3390/ijms23052437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910288/
https://www.ncbi.nlm.nih.gov/pubmed/35269583
http://dx.doi.org/10.3390/ijms23052437

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