Cognate DNA Recognition by Engrailed Homeodomain Involves A Conformational Change Controlled via An Electrostatic-Spring-Loaded Latch

Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact with the cognate site with high affinity and more weakly with any...

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Detalles Bibliográficos
Autores principales: D’Amelio, Nicola, Tanielian, Benjamin, Sadqi, Mourad, López-Navajas, Pilar, Muñoz, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910618/
https://www.ncbi.nlm.nih.gov/pubmed/35269555
http://dx.doi.org/10.3390/ijms23052412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910618/
https://www.ncbi.nlm.nih.gov/pubmed/35269555
http://dx.doi.org/10.3390/ijms23052412

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