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Cognate DNA Recognition by Engrailed Homeodomain Involves A Conformational Change Controlled via An Electrostatic-Spring-Loaded Latch
Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact with the cognate site with high affinity and more weakly with any...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910618/ https://www.ncbi.nlm.nih.gov/pubmed/35269555 http://dx.doi.org/10.3390/ijms23052412 |