PSMD14 Targeting Triggers Paraptosis in Breast Cancer Cells by Inducing Proteasome Inhibition and Ca(2+) Imbalance

PSMD14, a subunit of the 19S regulatory particles of the 26S proteasome, was recently identified as a potential prognostic marker and therapeutic target in diverse human cancers. Here, we show that the silencing and pharmacological blockade of PSMD14 in MDA-MB 435S breast cancer cells induce parapto...

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Detalles Bibliográficos
Autores principales: Lee, Hong-Jae, Lee, Dong-Min, Seo, Min-Ji, Kang, Ho-Chul, Kwon, Seok-Kyu, Choi, Kyeong-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910635/
https://www.ncbi.nlm.nih.gov/pubmed/35269789
http://dx.doi.org/10.3390/ijms23052648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910635/
https://www.ncbi.nlm.nih.gov/pubmed/35269789
http://dx.doi.org/10.3390/ijms23052648

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