Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model

Chronic neuroinflammation has been considered to be involved in the progressive dopaminergic neurodegeneration in Parkinson’s disease (PD). However, the mechanisms remain unknown. Accumulating evidence indicated a key role of the blood–brain barrier (BBB) dysfunction in neurological disorders. This...

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Detalles Bibliográficos
Autores principales: Ruan, Zhengzheng, Zhang, Dongdong, Huang, Ruixue, Sun, Wei, Hou, Liyan, Zhao, Jie, Wang, Qingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910886/
https://www.ncbi.nlm.nih.gov/pubmed/35269933
http://dx.doi.org/10.3390/ijms23052793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910886/
https://www.ncbi.nlm.nih.gov/pubmed/35269933
http://dx.doi.org/10.3390/ijms23052793

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