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Microglial Activation Damages Dopaminergic Neurons through MMP-2/-9-Mediated Increase of Blood-Brain Barrier Permeability in a Parkinson’s Disease Mouse Model
Chronic neuroinflammation has been considered to be involved in the progressive dopaminergic neurodegeneration in Parkinson’s disease (PD). However, the mechanisms remain unknown. Accumulating evidence indicated a key role of the blood–brain barrier (BBB) dysfunction in neurological disorders. This...
Autores principales: | Ruan, Zhengzheng, Zhang, Dongdong, Huang, Ruixue, Sun, Wei, Hou, Liyan, Zhao, Jie, Wang, Qingshan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8910886/ https://www.ncbi.nlm.nih.gov/pubmed/35269933 http://dx.doi.org/10.3390/ijms23052793 |
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