Double-Stranded RNA Enhances Matrix Metalloproteinase-1 and -13 Expressions through TLR3-Dependent Activation of Transglutaminase 2 in Dermal Fibroblasts

UV-irradiation induces the secretion of double-stranded RNA (dsRNA) derived from damaged noncoding RNAs in keratinocytes, which enhance the expression of matrix metalloproteinases (MMP) in non-irradiated dermal fibroblasts, leading to dysregulation of extracellular matrix homeostasis. However, the s...

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Detalles Bibliográficos
Autores principales: Hong, Ah-Young, Lee, Seok-Jin, Lee, Ki Baek, Shin, Ji-Woong, Jeong, Eui Man, Kim, In-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911030/
https://www.ncbi.nlm.nih.gov/pubmed/35269849
http://dx.doi.org/10.3390/ijms23052709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911030/
https://www.ncbi.nlm.nih.gov/pubmed/35269849
http://dx.doi.org/10.3390/ijms23052709

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