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Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911353/ https://www.ncbi.nlm.nih.gov/pubmed/35268403 http://dx.doi.org/10.3390/jcm11051313 |
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author | Mansouri, Atena Reiner, Željko Ruscica, Massimiliano Tedeschi-Reiner, Eugenia Radbakhsh, Shabnam Bagheri Ekta, Mariam Sahebkar, Amirhossein |
author_facet | Mansouri, Atena Reiner, Željko Ruscica, Massimiliano Tedeschi-Reiner, Eugenia Radbakhsh, Shabnam Bagheri Ekta, Mariam Sahebkar, Amirhossein |
author_sort | Mansouri, Atena |
collection | PubMed |
description | Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i.e., their pleiotropic effects, might be beneficial in the prevention or treatment of many diseases. This review discusses the antioxidant effects of statins achieved by modulating the nuclear factor erythroid 2 related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway in different organs and diseases. Nrf2 and other proteins involved in the Nrf2/HO-1 signaling pathway have a crucial role in cellular responses to oxidative stress, which is a risk factor for ASCVD. Statins can significantly increase the DNA-binding activity of Nrf2 and induce the expression of its target genes, such as HO-1 and glutathione peroxidase) GPx, (thus protecting the cells against oxidative stress. Antioxidant and anti-inflammatory properties of statins, which are independent of their lipid-lowering effects, could be partly explained by the modulation of the Nrf2/HO-1 pathway. |
format | Online Article Text |
id | pubmed-8911353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89113532022-03-11 Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases Mansouri, Atena Reiner, Željko Ruscica, Massimiliano Tedeschi-Reiner, Eugenia Radbakhsh, Shabnam Bagheri Ekta, Mariam Sahebkar, Amirhossein J Clin Med Review Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i.e., their pleiotropic effects, might be beneficial in the prevention or treatment of many diseases. This review discusses the antioxidant effects of statins achieved by modulating the nuclear factor erythroid 2 related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway in different organs and diseases. Nrf2 and other proteins involved in the Nrf2/HO-1 signaling pathway have a crucial role in cellular responses to oxidative stress, which is a risk factor for ASCVD. Statins can significantly increase the DNA-binding activity of Nrf2 and induce the expression of its target genes, such as HO-1 and glutathione peroxidase) GPx, (thus protecting the cells against oxidative stress. Antioxidant and anti-inflammatory properties of statins, which are independent of their lipid-lowering effects, could be partly explained by the modulation of the Nrf2/HO-1 pathway. MDPI 2022-02-27 /pmc/articles/PMC8911353/ /pubmed/35268403 http://dx.doi.org/10.3390/jcm11051313 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mansouri, Atena Reiner, Željko Ruscica, Massimiliano Tedeschi-Reiner, Eugenia Radbakhsh, Shabnam Bagheri Ekta, Mariam Sahebkar, Amirhossein Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases |
title | Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases |
title_full | Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases |
title_fullStr | Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases |
title_full_unstemmed | Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases |
title_short | Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases |
title_sort | antioxidant effects of statins by modulating nrf2 and nrf2/ho-1 signaling in different diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911353/ https://www.ncbi.nlm.nih.gov/pubmed/35268403 http://dx.doi.org/10.3390/jcm11051313 |
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