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Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases

Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i...

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Autores principales: Mansouri, Atena, Reiner, Željko, Ruscica, Massimiliano, Tedeschi-Reiner, Eugenia, Radbakhsh, Shabnam, Bagheri Ekta, Mariam, Sahebkar, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911353/
https://www.ncbi.nlm.nih.gov/pubmed/35268403
http://dx.doi.org/10.3390/jcm11051313
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author Mansouri, Atena
Reiner, Željko
Ruscica, Massimiliano
Tedeschi-Reiner, Eugenia
Radbakhsh, Shabnam
Bagheri Ekta, Mariam
Sahebkar, Amirhossein
author_facet Mansouri, Atena
Reiner, Željko
Ruscica, Massimiliano
Tedeschi-Reiner, Eugenia
Radbakhsh, Shabnam
Bagheri Ekta, Mariam
Sahebkar, Amirhossein
author_sort Mansouri, Atena
collection PubMed
description Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i.e., their pleiotropic effects, might be beneficial in the prevention or treatment of many diseases. This review discusses the antioxidant effects of statins achieved by modulating the nuclear factor erythroid 2 related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway in different organs and diseases. Nrf2 and other proteins involved in the Nrf2/HO-1 signaling pathway have a crucial role in cellular responses to oxidative stress, which is a risk factor for ASCVD. Statins can significantly increase the DNA-binding activity of Nrf2 and induce the expression of its target genes, such as HO-1 and glutathione peroxidase) GPx, (thus protecting the cells against oxidative stress. Antioxidant and anti-inflammatory properties of statins, which are independent of their lipid-lowering effects, could be partly explained by the modulation of the Nrf2/HO-1 pathway.
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spelling pubmed-89113532022-03-11 Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases Mansouri, Atena Reiner, Željko Ruscica, Massimiliano Tedeschi-Reiner, Eugenia Radbakhsh, Shabnam Bagheri Ekta, Mariam Sahebkar, Amirhossein J Clin Med Review Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four decades. Antioxidant and anti-inflammatory properties which are independent of the lipid-lowering effects of statins, i.e., their pleiotropic effects, might be beneficial in the prevention or treatment of many diseases. This review discusses the antioxidant effects of statins achieved by modulating the nuclear factor erythroid 2 related factor 2/ heme oxygenase-1 (Nrf2/HO-1) pathway in different organs and diseases. Nrf2 and other proteins involved in the Nrf2/HO-1 signaling pathway have a crucial role in cellular responses to oxidative stress, which is a risk factor for ASCVD. Statins can significantly increase the DNA-binding activity of Nrf2 and induce the expression of its target genes, such as HO-1 and glutathione peroxidase) GPx, (thus protecting the cells against oxidative stress. Antioxidant and anti-inflammatory properties of statins, which are independent of their lipid-lowering effects, could be partly explained by the modulation of the Nrf2/HO-1 pathway. MDPI 2022-02-27 /pmc/articles/PMC8911353/ /pubmed/35268403 http://dx.doi.org/10.3390/jcm11051313 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mansouri, Atena
Reiner, Željko
Ruscica, Massimiliano
Tedeschi-Reiner, Eugenia
Radbakhsh, Shabnam
Bagheri Ekta, Mariam
Sahebkar, Amirhossein
Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
title Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
title_full Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
title_fullStr Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
title_full_unstemmed Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
title_short Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
title_sort antioxidant effects of statins by modulating nrf2 and nrf2/ho-1 signaling in different diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911353/
https://www.ncbi.nlm.nih.gov/pubmed/35268403
http://dx.doi.org/10.3390/jcm11051313
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