Cargando…

Design, Synthesis, and In Vivo Evaluation of C1-Linked 4,5-Epoxymorphinan Haptens for Heroin Vaccines

In our continuing effort to develop effective anti-heroin vaccines as potential medications for the treatment of opioid use disorder, herein we present the design and synthesis of the haptens: 1-AmidoMorHap (1), 1-AmidoMorHap epimer (2), 1 Amido-DihydroMorHap (3), and 1 Amido-DihydroMorHap epimer (4...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sulima, Agnieszka, Li, Fuying, Morgan, Jeffrey Brian, Truong, Phong, Antoline, Joshua F. G., Oertel, Therese, Barrientos, Rodell C., Torres, Oscar B., Beck, Zoltan, Imler, Gregory H., Deschamps, Jeffrey R., Matyas, Gary R., Jacobson, Arthur E., Rice, Kenner C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8911913/ https://www.ncbi.nlm.nih.gov/pubmed/35268659 http://dx.doi.org/10.3390/molecules27051553

Ejemplares similares

Synthesis and immunological effects of C14-linked 4,5-epoxymorphinan analogues as novel heroin vaccine haptens
por: Gutman, Eugene S., et al.
Publicado: (2021)

A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse
por: Sulima, Agnieszka, et al.
Publicado: (2017)

A rapid solution-based method for determining the affinity of heroin hapten-induced antibodies to heroin, its metabolites, and other opioids
por: Torres, Oscar B., et al.
Publicado: (2018)

Characterization and optimization of heroin hapten-BSA conjugates: method development for the synthesis of reproducible hapten-based vaccines
por: Torres, Oscar B., et al.
Publicado: (2014)

Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice
por: Barrientos, Rodell C., et al.
Publicado: (2021)

A simple nonradioactive method for the determination of the binding affinities of antibodies induced by hapten bioconjugates for drugs of abuse
por: Torres, Oscar B., et al.
Publicado: (2015)

A Rapid Method for Direct Quantification of Antibody Binding-Site Concentration in Serum
por: Abucayon, Erwin G., et al.
Publicado: (2022)

Heroin-HIV-1 (H2) vaccine: induction of dual immunologic effects with a heroin hapten-conjugate and an HIV-1 envelope V2 peptide with liposomal lipid A as an adjuvant
por: Torres, Oscar B., et al.
Publicado: (2017)

Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice
por: Komla, Essie, et al.
Publicado: (2021)

Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice
por: Ban, Bhupal, et al.
Publicado: (2021)

Novel Vaccine That Blunts Fentanyl Effects and Sequesters Ultrapotent Fentanyl Analogues
por: Barrientos, Rodell C., et al.
Publicado: (2020)

Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible μ Opioid Receptor Antagonist Effects
por: Moynihan, Humphrey A., et al.
Publicado: (2012)

Synthesis and Pharmacological Evaluation of Enantiopure N-Substituted Ortho-c Oxide-Bridged 5-Phenylmorphans
por: Li, Fuying, et al.
Publicado: (2022)

Improved Admixture Vaccine of Fentanyl and Heroin Hapten Immunoconjugates: Antinociceptive Evaluation of Fentanyl-Contaminated Heroin
por: Hwang, Candy S., et al.
Publicado: (2018)

A chemically contiguous hapten approach for a heroin–fentanyl vaccine
por: Natori, Yoshihiro, et al.
Publicado: (2019)

κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats
por: Marchette, Renata C.N., et al.
Publicado: (2021)

Synthesis of Enantiopure 10-Nornaltrexones in the Search for Toll-like Receptor 4 Antagonists and Opioid Ligands
por: Selfridge, Brandon R., et al.
Publicado: (2014)

A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans
por: Chambers, Dana R., et al.
Publicado: (2023)

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans
por: Lutz, Joshua A., et al.
Publicado: (2023)

Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats
por: Gannon, Brenda M., et al.
Publicado: (2018)

CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES : IV. EXPERIMENTAL CONDITIONS FOR THE INDUCTION OF HAPTEN-SPECIFIC TOLERANCE OR FOR THE STIMULATION OF ANTI-HAPTEN ANAMNESTIC RESPONSES BY "NONIMMUNOGENIC" HAPTEN-POLYPEPTIDE CONJUGATES
por: Katz, David H., et al.
Publicado: (1971)

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists
por: Chambers, Dana R., et al.
Publicado: (2022)

Gamma delta T cells recognize haptens and mount a hapten-specific response
por: Zeng, Xun, et al.
Publicado: (2014)

Incompatibilities of Heroin and Heroin Hydrochloride
Publicado: (1901)

ELICITATION OF DELAYED ALLERGIC SKIN REACTIONS WITH HAPTENS: THE DEPENDENCE OF ELICITATION ON HAPTEN COMBINATION WITH PROTEIN
por: Eisen, Herman N., et al.
Publicado: (1952)

ON THE USE OF ADSORBENTS IN IMMUNIZATIONS WITH HAPTENS
por: Jacobs, John
Publicado: (1934)

DELAYED HYPERSENSITIVITY TO HAPTEN-PROTEIN CONJUGATES : II. ANTI-HAPTEN SPECIFICITY AND THE HETEROGENEITY OF THE DELAYED RESPONSE
por: Silverstein, Arthur M., et al.
Publicado: (1962)

DELAYED HYPERSENSITIVITY TO HAPTEN-PROTEIN CONJUGATES : I. THE EFFECT OF CARRIER PROTEIN AND SITE OF ATTACHMENT TO HAPTEN
por: Cell, P. G. H., et al.
Publicado: (1962)

Hapten-reactive inducer T cells. I. Definition of two classes of hapten- specific inducer cells
Publicado: (1983)

Suppressor cells in tolerance to contact sensitivity active against hapten-syngeneic and hapten-allogeneic determinants
Publicado: (1977)

Role of BNST CRFR1 Receptors in Incubation of Fentanyl Seeking
por: Gyawali, Utsav, et al.
Publicado: (2020)

Corrigendum: Role of BNST CRFR1 Receptors in Incubation of Fentanyl Seeking
por: Gyawali, Utsav, et al.
Publicado: (2021)

Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone
por: Manke, Hayley N., et al.
Publicado: (2023)

Heroin-induced headache in female heroin addicts
por: Li, Li, et al.
Publicado: (2020)

Haptenation of Macrophage Migration Inhibitory Factor: A Potential Biomarker for Contact Hypersensitivity
por: Ndreu, Lorena, et al.
Publicado: (2022)

Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. I. Detection and characterization of hapten-reactive suppressor T-cell activity in mice immunized with hapten-isologous protein conjugate
por: Yamamoto, H, et al.
Publicado: (1977)

HAPTEN-CARRIER RELATIONSHIPS OF ISOANTIGENS : A MODEL FOR IMMUNOLOGICAL MATURATION BASED ON THE CONVERSION OF HAPTENS TO CARRIERS BY ANTIBODY
por: McBride, Raymond A., et al.
Publicado: (1970)

PERSISTENCE OF HAPTEN-ANTIBODY COMPLEXES IN THE CIRCULATION OF IMMUNIZED ANIMALS AFTER A SINGLE INTRAVENOUS INJECTION OF HAPTEN
por: Schmidt, Donald H., et al.
Publicado: (1974)

Hapten-specific hemolytic plaque assays usually fail to detect most of the diversity in the anti-hapten response
Publicado: (1977)

Altered Hapten Ligands Antagonize Trinitrophenyl-specific Cytotoxic T Cells and Block Internalization of Hapten-specific Receptors
por: Preckel, Tobias, et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_0jcaf9ns5o7vlpss8t08usc5ou