Promiscuous Lipase-Catalyzed Markovnikov Addition of H-Phosphites to Vinyl Esters for the Synthesis of Cytotoxic α-Acyloxy Phosphonate Derivatives

An enzymatic route for phosphorous-carbon- bond formation is developed by discovering new promiscuous activity of lipase. This biocatalytic transformation of phosphorous-carbon- bond addition leads to biologically and pharmacologically relevant α-acyloxy phosphonates with methyl group in α-position....

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Detalles Bibliográficos
Autores principales: Kowalczyk, Paweł, Koszelewski, Dominik, Gawdzik, Barbara, Samsonowicz-Górski, Jan, Kramkowski, Karol, Wypych, Aleksandra, Lizut, Rafał, Ostaszewski, Ryszard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912074/
https://www.ncbi.nlm.nih.gov/pubmed/35269205
http://dx.doi.org/10.3390/ma15051975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912074/
https://www.ncbi.nlm.nih.gov/pubmed/35269205
http://dx.doi.org/10.3390/ma15051975

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