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Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk

Background: Red and processed meat consumption has been consistently associated with increased risk of colorectal cancer (CRC), but the association for fish intake is unclear. Evidence using objective dietary assessment approaches to evaluate these associations is sparse. Objectives: We aim to inves...

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Autores principales: Wang, Fenglei, Chandler, Paulette D., Zeleznik, Oana A., Wu, Kana, Wu, You, Yin, Kanhua, Song, Rui, Avila-Pacheco, Julian, Clish, Clary B., Meyerhardt, Jeffrey A., Zhang, Xuehong, Song, Mingyang, Ogino, Shuji, Lee, I-Min, Eliassen, A. Heather, Liang, Liming, Smith-Warner, Stephanie A., Willett, Walter C., Giovannucci, Edward L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912563/
https://www.ncbi.nlm.nih.gov/pubmed/35267954
http://dx.doi.org/10.3390/nu14050978
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author Wang, Fenglei
Chandler, Paulette D.
Zeleznik, Oana A.
Wu, Kana
Wu, You
Yin, Kanhua
Song, Rui
Avila-Pacheco, Julian
Clish, Clary B.
Meyerhardt, Jeffrey A.
Zhang, Xuehong
Song, Mingyang
Ogino, Shuji
Lee, I-Min
Eliassen, A. Heather
Liang, Liming
Smith-Warner, Stephanie A.
Willett, Walter C.
Giovannucci, Edward L.
author_facet Wang, Fenglei
Chandler, Paulette D.
Zeleznik, Oana A.
Wu, Kana
Wu, You
Yin, Kanhua
Song, Rui
Avila-Pacheco, Julian
Clish, Clary B.
Meyerhardt, Jeffrey A.
Zhang, Xuehong
Song, Mingyang
Ogino, Shuji
Lee, I-Min
Eliassen, A. Heather
Liang, Liming
Smith-Warner, Stephanie A.
Willett, Walter C.
Giovannucci, Edward L.
author_sort Wang, Fenglei
collection PubMed
description Background: Red and processed meat consumption has been consistently associated with increased risk of colorectal cancer (CRC), but the association for fish intake is unclear. Evidence using objective dietary assessment approaches to evaluate these associations is sparse. Objectives: We aim to investigate the plasma metabolite profiles related to red meat, poultry, and fish consumption and examine their associations with CRC risk. Methods: We measured plasma metabolites among 5269 participants from the Nurses’ Health Study (NHS), NHSII, and Health Professionals Follow-Up study (HPFS). We calculated partial Spearman correlations between each metabolite and self-reported intake of seven red meat, poultry, and fish groups. Metabolite profile scores correlated to self-reported dietary intakes were developed using elastic net regression. Associations between self-reported intakes, metabolite profile scores, and subsequent CRC risk were further evaluated using conditional logistic regression among 559 matched (1:1) case-control pairs in NHS/HPFS and replicated among 266 pairs in Women’s Health Study. Results: Plasma metabolites, especially highly unsaturated lipids, were differentially associated with red meat and fish groups. Metabolite profile scores for each food group were significantly correlated with the corresponding self-reported dietary intake. A higher dietary intake of processed red meat was associated with a higher risk of CRC (pooled OR per 1 SD, 1.15; 95% CI: 1.03, 1.29). In contrast, higher metabolite profile scores for all fish groups, not dietary intakes, were consistently associated with a lower CRC risk: the pooled OR per 1 SD was 0.86 (95% CI: 0.78, 0.96) for total fish, 0.86 (95% CI: 0.77, 0.96) for dark meat fish, and 0.87 (95% CI: 0.78, 0.97) for canned tuna fish. No significant associations were found for other food groups. Conclusions: Red meat and fish intake exhibited systematically different plasma metabolite profiles. Plasma metabolite profile of fish intake was inversely associated with CRC risk.
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spelling pubmed-89125632022-03-11 Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk Wang, Fenglei Chandler, Paulette D. Zeleznik, Oana A. Wu, Kana Wu, You Yin, Kanhua Song, Rui Avila-Pacheco, Julian Clish, Clary B. Meyerhardt, Jeffrey A. Zhang, Xuehong Song, Mingyang Ogino, Shuji Lee, I-Min Eliassen, A. Heather Liang, Liming Smith-Warner, Stephanie A. Willett, Walter C. Giovannucci, Edward L. Nutrients Article Background: Red and processed meat consumption has been consistently associated with increased risk of colorectal cancer (CRC), but the association for fish intake is unclear. Evidence using objective dietary assessment approaches to evaluate these associations is sparse. Objectives: We aim to investigate the plasma metabolite profiles related to red meat, poultry, and fish consumption and examine their associations with CRC risk. Methods: We measured plasma metabolites among 5269 participants from the Nurses’ Health Study (NHS), NHSII, and Health Professionals Follow-Up study (HPFS). We calculated partial Spearman correlations between each metabolite and self-reported intake of seven red meat, poultry, and fish groups. Metabolite profile scores correlated to self-reported dietary intakes were developed using elastic net regression. Associations between self-reported intakes, metabolite profile scores, and subsequent CRC risk were further evaluated using conditional logistic regression among 559 matched (1:1) case-control pairs in NHS/HPFS and replicated among 266 pairs in Women’s Health Study. Results: Plasma metabolites, especially highly unsaturated lipids, were differentially associated with red meat and fish groups. Metabolite profile scores for each food group were significantly correlated with the corresponding self-reported dietary intake. A higher dietary intake of processed red meat was associated with a higher risk of CRC (pooled OR per 1 SD, 1.15; 95% CI: 1.03, 1.29). In contrast, higher metabolite profile scores for all fish groups, not dietary intakes, were consistently associated with a lower CRC risk: the pooled OR per 1 SD was 0.86 (95% CI: 0.78, 0.96) for total fish, 0.86 (95% CI: 0.77, 0.96) for dark meat fish, and 0.87 (95% CI: 0.78, 0.97) for canned tuna fish. No significant associations were found for other food groups. Conclusions: Red meat and fish intake exhibited systematically different plasma metabolite profiles. Plasma metabolite profile of fish intake was inversely associated with CRC risk. MDPI 2022-02-25 /pmc/articles/PMC8912563/ /pubmed/35267954 http://dx.doi.org/10.3390/nu14050978 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Fenglei
Chandler, Paulette D.
Zeleznik, Oana A.
Wu, Kana
Wu, You
Yin, Kanhua
Song, Rui
Avila-Pacheco, Julian
Clish, Clary B.
Meyerhardt, Jeffrey A.
Zhang, Xuehong
Song, Mingyang
Ogino, Shuji
Lee, I-Min
Eliassen, A. Heather
Liang, Liming
Smith-Warner, Stephanie A.
Willett, Walter C.
Giovannucci, Edward L.
Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
title Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
title_full Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
title_fullStr Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
title_full_unstemmed Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
title_short Plasma Metabolite Profiles of Red Meat, Poultry, and Fish Consumption, and Their Associations with Colorectal Cancer Risk
title_sort plasma metabolite profiles of red meat, poultry, and fish consumption, and their associations with colorectal cancer risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912563/
https://www.ncbi.nlm.nih.gov/pubmed/35267954
http://dx.doi.org/10.3390/nu14050978
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