Targeting EDEM protects against ER stress and improves development and survival in C. elegans

EDEM-1, EDEM-2 and EDEM-3 are key players for the quality control of newly synthesized proteins in the endoplasmic reticulum (ER) by accelerating disposal and degradation of misfolded proteins through ER Associated Degradation (ERAD). Although many previous studies reported the role of individual ER...

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Detalles Bibliográficos
Autores principales: Ghenea, Simona, Chiritoiu, Marioara, Tacutu, Robi, Miranda-Vizuete, Antonio, Petrescu, Stefana Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912907/
https://www.ncbi.nlm.nih.gov/pubmed/35192599
http://dx.doi.org/10.1371/journal.pgen.1010069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912907/
https://www.ncbi.nlm.nih.gov/pubmed/35192599
http://dx.doi.org/10.1371/journal.pgen.1010069

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