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Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo
The human endogenous retrovirus type-H (HERVH) family is expressed in the preimplantation embryo. A subset of these elements are specifically transcribed in pluripotent stem cells where they appear to exert regulatory activities promoting self-renewal and pluripotency. How HERVH elements achieve suc...
Autores principales: | Carter, Thomas A, Singh, Manvendra, Dumbović, Gabrijela, Chobirko, Jason D, Rinn, John L, Feschotte, Cédric |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912925/ https://www.ncbi.nlm.nih.gov/pubmed/35179489 http://dx.doi.org/10.7554/eLife.76257 |
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