Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements

Lon protease is a conserved ATP-dependent serine protease composed of an AAA+ domain that mechanically unfolds substrates and a serine protease domain that degrades these unfolded substrates. In yeast, dysregulation of Lon protease (PIM1) attenuates lifespan and leads to gross mitochondrial morpholo...

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Detalles Bibliográficos
Autores principales: Yang, Jie, Song, Albert S., Wiseman, R. Luke, Lander, Gabriel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913295/
https://www.ncbi.nlm.nih.gov/pubmed/35143841
http://dx.doi.org/10.1016/j.jbc.2022.101694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913295/
https://www.ncbi.nlm.nih.gov/pubmed/35143841
http://dx.doi.org/10.1016/j.jbc.2022.101694

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