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Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements

Lon protease is a conserved ATP-dependent serine protease composed of an AAA+ domain that mechanically unfolds substrates and a serine protease domain that degrades these unfolded substrates. In yeast, dysregulation of Lon protease (PIM1) attenuates lifespan and leads to gross mitochondrial morpholo...

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Detalles Bibliográficos
Autores principales:	Yang, Jie, Song, Albert S., Wiseman, R. Luke, Lander, Gabriel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913295/ https://www.ncbi.nlm.nih.gov/pubmed/35143841 http://dx.doi.org/10.1016/j.jbc.2022.101694

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