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Tafenoquine exhibits broad spectrum antifungal activity at clinically relevant concentrations in vitro and decreases lung fungal burden in an invasive pulmonary model of Rhizopus in vivo
BACKGROUND: Tafenoquine is active against a broad range of pathogens and accumulates extensively in the lung. We profiled the susceptibility of fungal pathogens to tafenoquine in vitro and in vivo. METHODS: Minimum inhibitory concentrations [MICs] of medically important fungal pathogens were determi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913336/ https://www.ncbi.nlm.nih.gov/pubmed/35284080 http://dx.doi.org/10.1016/j.nmni.2022.100964 |