RNA-binding protein complex LIN28/MSI2 enhances cancer stem cell-like properties by modulating Hippo-YAP1 signaling and independently of Let-7

The RNA binding protein LIN28 directly modulates the stability and translation of target mRNAs independently of Let-7; however, the key downstream targets of LIN28 in this process are largely unknown. Here, we revealed that Hippo signaling effector YAP1 functioned as a key downstream regulator of LI...

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Detalles Bibliográficos
Autores principales: Zou, Hailin, Luo, Juan, Guo, Yibo, Liu, Yuhong, Wang, Yun, Deng, Liang, Li, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913359/
https://www.ncbi.nlm.nih.gov/pubmed/35102250
http://dx.doi.org/10.1038/s41388-022-02198-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913359/
https://www.ncbi.nlm.nih.gov/pubmed/35102250
http://dx.doi.org/10.1038/s41388-022-02198-w

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