Cargando…

METTL3 promotes intrahepatic cholangiocarcinoma progression by regulating IFIT2 expression in an m(6)A-YTHDF2-dependent manner

N6-methyladenosine (m(6)A) RNA methylation has recently been found involving in regulatory mechanism of the tumor progression. Our aim was to explore the biological function and clinical significance of the m(6)A methyltransferase METTL3 in intrahepatic cholangiocarcinoma (ICC). In this study, we re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Qiong-Cong, Tien, Yi-Chih, Shi, Yin-Hao, Chen, Siyun, Zhu, Ying-Qin, Huang, Xi-Tai, Huang, Chen-Song, Zhao, Wei, Yin, Xiao-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8913368/ https://www.ncbi.nlm.nih.gov/pubmed/35094011 http://dx.doi.org/10.1038/s41388-022-02185-1

Ejemplares similares

YTHDF2 promotes intrahepatic cholangiocarcinoma progression and desensitises cisplatin treatment by increasing CDKN1B mRNA degradation
por: Huang, Chen‐Song, et al.
Publicado: (2022)

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m(6)A-YTHDF2-dependent manner
por: Li, Jiaren, et al.
Publicado: (2022)

Therapeutic Targeting of CDK7 Suppresses Tumor Progression in Intrahepatic Cholangiocarcinoma
por: Chen, Hua-Dong, et al.
Publicado: (2020)

RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis
por: Li, Yi, et al.
Publicado: (2022)

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus
por: Zhao, Lingcai, et al.
Publicado: (2022)

Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing’s sarcoma
por: Jiang, Jie, et al.
Publicado: (2022)

MFAP5 facilitates the aggressiveness of intrahepatic Cholangiocarcinoma by activating the Notch1 signaling pathway
por: Li, Jian-Hui, et al.
Publicado: (2019)

METTL3/m(6)A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma
por: Ge, Fangfang, et al.
Publicado: (2022)

The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus
por: Luo, Qing, et al.
Publicado: (2020)

O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N(6)-methyladenosine-dependent manner
por: Yang, Yang, et al.
Publicado: (2023)

YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
por: Zhu, Junlong, et al.
Publicado: (2023)

IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA
por: Fleith, Renata C, et al.
Publicado: (2018)

Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis
por: Chen, Limin, et al.
Publicado: (2017)

METTL3/YTHDF2 m6A axis promotes the malignant progression of bladder cancer by epigenetically suppressing RRAS
por: Chen, Jie-Xun, et al.
Publicado: (2023)

METTL3 facilitates immunosurveillance by inhibiting YTHDF2-mediated NLRC5 mRNA degradation in endometrial cancer
por: Zhan, Lei, et al.
Publicado: (2023)

METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5
por: Zhou, Dan, et al.
Publicado: (2021)

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism
por: Wang, Yongjie, et al.
Publicado: (2022)

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner
por: Chen, Yangyang, et al.
Publicado: (2023)

METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m(6)A-YTHDF2–dependent mechanism
por: Hou, Xiaoxue, et al.
Publicado: (2023)

Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma
por: Chen, Xing, et al.
Publicado: (2022)

The diagnostic and prognostic value of UBE2T in intrahepatic cholangiocarcinoma
por: Yu, Hua, et al.
Publicado: (2020)

LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia
por: Guo, Bo, et al.
Publicado: (2022)

Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
por: Wang, Fang, et al.
Publicado: (2023)

METTL3 promotes cell cycle progression via m(6)A/YTHDF1-dependent regulation of CDC25B translation
por: Li, Huifeng, et al.
Publicado: (2022)

Peritumoral SPARC expression and patient outcome with resectable intrahepatic cholangiocarcinoma
por: Cheng, Chi-Tung, et al.
Publicado: (2015)

Overexpression of UHRF2 in intrahepatic cholangiocarcinoma and its clinical significance
por: Peng, Rui, et al.
Publicado: (2017)

Proteome Landscapes of Human Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
por: Yi, Xiao, et al.
Publicado: (2023)

PA2G4 promotes the metastasis of hepatocellular carcinoma by stabilizing FYN mRNA in a YTHDF2-dependent manner
por: Sun, Sheng, et al.
Publicado: (2022)

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation
por: Li, Jiong, et al.
Publicado: (2021)

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner
por: Chen, Hengyu, et al.
Publicado: (2022)

Intrahepatic Sarcomatoid Cholangiocarcinoma
por: Malhotra, Shalini, et al.
Publicado: (2010)

Asbestos and Intrahepatic Cholangiocarcinoma
por: Brandi, Giovanni, et al.
Publicado: (2020)

Management of Intrahepatic Cholangiocarcinoma
por: Kodali, Sudha, et al.
Publicado: (2021)

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3
por: Schindewolf, Craig, et al.
Publicado: (2022)

SARS-CoV-2 Uses Nonstructural Protein 16 To Evade Restriction by IFIT1 and IFIT3
por: Schindewolf, Craig, et al.
Publicado: (2023)

YTHDF2 facilitates aggresome formation via UPF1 in an m(6)A-independent manner
por: Hwang, Hyun Jung, et al.
Publicado: (2023)

N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification
por: Wang, Qianqing, et al.
Publicado: (2020)

Is Lymphadenectomy Reasonable for Elderly Intrahepatic Cholangiocarcinoma Patients?
por: Lin, Qianyi, et al.
Publicado: (2023)

PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2
por: Shen, Hui, et al.
Publicado: (2018)

SHMT2 Overexpression Predicts Poor Prognosis in Intrahepatic Cholangiocarcinoma
por: Ning, Shanglei, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_45dci95sn7m35d251l8d74fe2i